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KRAS inhibitor resistance: before calling five genes therapeutic targets
In BigWonder, I compared public KRAS-inhibitor resistance evidence for five genes. Broad essentiality led me to exclude USP36 from promotion as a selective new target; the other four…
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Pneumocystis: could its genetic instructions be read differently?
A recurring mismatch in public genetic records raises a candidate explanation. I describe what agreement across records supports, why record counts are not sample counts, and what RNA…
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UNK-g: narrowing the identity of an unassigned protein
A protein can have a visible shape without an assigned gene identity. I summarize the evidence for Q38DP6 as a candidate for UNK-g, including why a first-place ranking…
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Reporting an average-starlight error in EXOFASTv2
Calculating starlight at an average distance gives a different answer from averaging the light itself. I reported this mismatch in EXOFASTv2 with a reproducible check. Both EXOFASTv2 and…
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A model card’s release year did not match the official announcement
I compared the Grok 4 release date on an EvalEval card with official sources and filed a correction request. This is a metadata check, not a finding that…
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Silent Pass: a private invitation code, a public record of use
Silent Pass is a Midnight prototype I worked on with Seongho Haam. His implementation and deployment work was paired with my review of product boundaries, failure handling and…